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pentobarbital will lower the level or result of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Pitolisant publicity is lowered by fifty% if coadministered with potent CYP3A4 inducers.benzhydrocodone/acetaminophen and pentobarbital each enhance sedation. Prevent or Use Alternate Drug. Restrict us